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Philip L Lorenzi Selected Research

Aspartate-Ammonia Ligase (Asparagine Synthetase)

6/2014The glutaminase activity of L-asparaginase is not required for anticancer activity against ASNS-negative cells.
8/2012Pancreatic tumor sensitivity to plasma L-asparagine starvation.
1/2009Asparagine synthetase: a new potential biomarker in ovarian cancer.
10/2008Asparagine synthetase is a predictive biomarker of L-asparaginase activity in ovarian cancer cell lines.
11/2006Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells.

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Philip L Lorenzi Research Topics

Disease

35Neoplasms (Cancer)
02/2022 - 11/2006
6Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2022 - 11/2006
5Breast Neoplasms (Breast Cancer)
01/2022 - 09/2007
5Leukemia
01/2022 - 11/2006
4Pancreatic Neoplasms (Pancreatic Cancer)
10/2021 - 08/2012
4Ovarian Neoplasms (Ovarian Cancer)
01/2014 - 11/2006
3Fibrosis (Cirrhosis)
01/2022 - 01/2021
3Brain Neoplasms (Brain Tumor)
01/2021 - 01/2018
3Carcinogenesis
01/2020 - 04/2017
2Melanoma (Melanoma, Malignant)
02/2022 - 01/2021
2Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2022 - 02/2016
2Glioblastoma (Glioblastoma Multiforme)
11/2021 - 01/2021
2Hepatocellular Carcinoma (Hepatoma)
10/2021 - 01/2021
2Hematologic Neoplasms (Hematological Malignancy)
01/2019 - 02/2016
2Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
01/2019 - 02/2016
2Genomic Instability
12/2009 - 09/2007
2Chromosome Aberrations (Chromosome Abnormalities)
09/2007 - 05/2007
1Breast Ductal Carcinoma
01/2022
1Cytopenia
01/2022
1Overnutrition
01/2022
1Adenocarcinoma of Lung
01/2022
1Fatty Liver
01/2022
1Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
01/2022
1Heart Failure
01/2022
1Inflammation (Inflammations)
01/2022
1Insulin Resistance
01/2022
1Cardiomyopathies (Cardiomyopathy)
01/2022
1Glioma (Gliomas)
11/2021
1Small Cell Lung Carcinoma (Small Cell Lung Cancer)
09/2021
1Head and Neck Neoplasms (Head and Neck Cancer)
01/2021
1Liver Cirrhosis (Hepatic Cirrhosis)
01/2021
1Adenocarcinoma
10/2020
1Pyruvate Kinase Deficiency of Red Cells
01/2020

Drug/Important Bio-Agent (IBA)

10Asparaginase (Elspar)FDA Link
01/2022 - 11/2006
7Proteins (Proteins, Gene)FDA Link
02/2022 - 05/2007
6Pharmaceutical PreparationsIBA
02/2022 - 05/2007
6EnzymesIBA
01/2022 - 11/2006
6Glucose (Dextrose)FDA LinkGeneric
01/2022 - 01/2018
6Biomarkers (Surrogate Marker)IBA
10/2021 - 11/2006
5Glutamine (L-Glutamine)FDA Link
01/2022 - 06/2014
5AsparagineIBA
10/2021 - 11/2006
5Aspartate-Ammonia Ligase (Asparagine Synthetase)IBA
06/2014 - 11/2006
4Fatty Acids (Saturated Fatty Acids)IBA
02/2022 - 01/2021
4DNA (Deoxyribonucleic Acid)IBA
10/2008 - 11/2006
3IACS-010759IBA
02/2022 - 01/2019
3GlutaminaseIBA
01/2022 - 06/2014
3NADP (NADPH)IBA
01/2022 - 01/2018
3Messenger RNA (mRNA)IBA
01/2018 - 05/2007
2Phosphotransferases (Kinase)IBA
01/2022 - 12/2009
2LipidsIBA
11/2021 - 10/2021
2Amino AcidsFDA Link
10/2021 - 01/2019
2AntigensIBA
01/2021 - 10/2020
2Immune Checkpoint InhibitorsIBA
01/2021 - 01/2018
2Adenosine Triphosphate (ATP)IBA
11/2019 - 01/2018
2ibrutinibIBA
01/2019 - 02/2016
2Antineoplastic Agents (Antineoplastics)IBA
01/2019 - 09/2007
2MicroRNAs (MicroRNA)IBA
10/2018 - 05/2007
2Small Interfering RNA (siRNA)IBA
07/2014 - 09/2007
2Biological ProductsIBA
06/2014 - 05/2007
1Mevalonic Acid (Mevalonate)IBA
02/2022
1Carbon-13IBA
02/2022
1Oxidoreductases (Dehydrogenase)IBA
02/2022
1Atorvastatin (Lipitor)FDA Link
02/2022
1Coenzyme A (CoA)IBA
02/2022
1CarbohydratesIBA
01/2022
1Anti-Bacterial Agents (Antibiotics)IBA
01/2022
1Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
01/2022
1B7-H1 AntigenIBA
01/2022
1DecitabineFDA Link
01/2022
1Thyroid Nuclear Factor 1IBA
01/2022
1Apoptosis Regulatory ProteinsIBA
01/2022
1venetoclaxIBA
01/2022
1Glutathione (Reduced Glutathione)IBA
01/2022
1CCR2 ReceptorsIBA
01/2022
1tyrosine receptor (receptor, tyrosine)IBA
01/2022
1Calcium-Calmodulin-Dependent Protein Kinase KinaseIBA
01/2022
1Insulin (Novolin)FDA Link
01/2022
1AZD5991IBA
01/2022
1Acyl-CoA Dehydrogenase (Medium-Chain Acyl-Coenzyme A Dehydrogenase)IBA
11/2021
1Deubiquitinating EnzymesIBA
10/2021
1Transcription Factors (Transcription Factor)IBA
09/2021
1PFK158IBA
09/2021
1CB-839IBA
01/2021
1Lactate Dehydrogenase 5IBA
01/2021
1Ketoglutaric Acids (Ketoglutaric Acid)IBA
01/2021
1Protein Kinases (Protein Kinase)IBA
01/2021
1Nonesterified Fatty Acids (NEFA)IBA
01/2021
1Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA
01/2021
1AntibodiesIBA
01/2021
1Interferon-gamma (Interferon, gamma)IBA
01/2021
1Peptides (Polypeptides)IBA
10/2020
1HLA-A Antigens (HLA-A)IBA
10/2020
1Lactic Acid (Lactate)FDA LinkGeneric
01/2020
1AmmoniaIBA
01/2020
1Glutamate DehydrogenaseIBA
01/2020
1Oxygen (Dioxygen)IBA
01/2020
1PhosphoenolpyruvateIBA
01/2020

Therapy/Procedure

12Therapeutics
01/2022 - 01/2011
4Drug Therapy (Chemotherapy)
01/2022 - 02/2016
1Immunotherapy
10/2020